The development of the Dutch protocol, and the research conducted from its practice, has become the basis for gender-related medical intervention in children all over the world; specifically, using drugs to block children's puberty and subsequently using cross-sex hormones and surgery to medicalize their 'transition.' The Dutch model has the reputation of being the “gold standard of care” for youth transgender medicine and is often cited when defending the use of puberty blockers and surgeries in minors and young adults.